Tuesday, April 30, 2013

SAGE to publish Canada's pre-eminent International Journal

SAGE to publish Canada's pre-eminent International Journal [ Back to EurekAlert! ] Public release date: 29-Apr-2013
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Contact: Katie Baker
katie.baker@sagepub.co.uk
020-732-48719
SAGE Publications

Los Angeles, CA (April 29, 2013) SAGE has begun a partnership with the Canadian International Council (CIC) and the Bill Graham Centre for Contemporary International History (CCIH) to publish Canada's pre-eminent journal of global policy analysis, International Journal. This long-standing journal publishes brief, policy-relevant articles alongside peer-reviewed scholarly assessments of interest to foreign policy makers, analysts and academics around the world. The journal publishes four times a year.

Established in 1946, International Journal is cross disciplinary in approach, combining the insights of history, political science and economics with anthropology and other social sciences to advance research and dialogue on global issues of significance.

"SAGE has a well-established global publishing programme in international relations and political science and we are delighted to welcome Canada's foremost foreign policy title to SAGE," said Karen Phillips, Editorial Director, SAGE. "We see a close alignment between SAGE and the CIC in our shared goal to advance research and support academic debate and policy discourse. International Journal plays an influential role in enabling the exchange of views and ideas on international relations and political science, and we look forward to developing this journal's global outreach as part of our world class international politics portfolio."

"When selecting a publisher, it was important for us to find someone who would both enhance our global impact and reader experience, while maintaining our unique brand and position. In SAGE we found a company whose infrastructure and global position would enable us to do this, and we look forward to benefitting from these during our partnership," commented Adam Chapnick, International Journal's co-editor.

"The Bill Graham Centre for Contemporary International History is pleased to join in the partnership with the Canadian International Council to publish Canada's leading international affairs journal. Our board member Dr. MacDonald will be co-editor and our conferences and speakers will provide content for this important journal that has deeply influenced the study of international affairs in Canada and elsewhere," said John English, Director of the CCIH.

Jennifer Jeffs, President of the Canadian International Council (CIC) added, "The journal is Canada's leading journal of international affairs and plays a key role in our mission to be a major voice in the international policy arena. SAGE is well known for its core strengths as a high quality publisher within international policy, and we see clear synergies with our core values and global publishing goals. We look forward to developing an influential relationship together."

###

SAGE is a leading international publisher of journals, books and electronic media for academic, educational, and professional markets. Since 1965, SAGE has helped inform and educate a global community of scholars, practitioners, researchers, and students spanning a wide range of subject areas including business, humanities, social sciences, and science, technology and medicine. SAGE has principal offices in Los Angeles, London, New Delhi, Singapore and Washington DC. http://www.sagepublicaions.com

International Journal (IJ) has been recognized as Canada's pre-eminent scholarly publication on international relations since its inception in 1946. Readers benefit from wide-ranging research and analysis by scholars, practitioners, and policy-makers, Canadian and non-Canadian.

Canadian International Council (CIC) is a non-partisan, nationwide council established to strengthen Canada's role in international affairs. It aims to advance research and dialogue on international affairs issues by supporting a Canadian foreign policy network that crosses academic disciplines, policy areas, and economic sectors.

Bill Graham Centre for Contemporary International History (CCIH) is a joint undertaking of Trinity College and the Munk School of Global Affairs at the University of Toronto. It promotes the study of recent international events from a historical standpoint, and pursues programs of research, teaching, publication and other activities to that end.


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SAGE to publish Canada's pre-eminent International Journal [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: Katie Baker
katie.baker@sagepub.co.uk
020-732-48719
SAGE Publications

Los Angeles, CA (April 29, 2013) SAGE has begun a partnership with the Canadian International Council (CIC) and the Bill Graham Centre for Contemporary International History (CCIH) to publish Canada's pre-eminent journal of global policy analysis, International Journal. This long-standing journal publishes brief, policy-relevant articles alongside peer-reviewed scholarly assessments of interest to foreign policy makers, analysts and academics around the world. The journal publishes four times a year.

Established in 1946, International Journal is cross disciplinary in approach, combining the insights of history, political science and economics with anthropology and other social sciences to advance research and dialogue on global issues of significance.

"SAGE has a well-established global publishing programme in international relations and political science and we are delighted to welcome Canada's foremost foreign policy title to SAGE," said Karen Phillips, Editorial Director, SAGE. "We see a close alignment between SAGE and the CIC in our shared goal to advance research and support academic debate and policy discourse. International Journal plays an influential role in enabling the exchange of views and ideas on international relations and political science, and we look forward to developing this journal's global outreach as part of our world class international politics portfolio."

"When selecting a publisher, it was important for us to find someone who would both enhance our global impact and reader experience, while maintaining our unique brand and position. In SAGE we found a company whose infrastructure and global position would enable us to do this, and we look forward to benefitting from these during our partnership," commented Adam Chapnick, International Journal's co-editor.

"The Bill Graham Centre for Contemporary International History is pleased to join in the partnership with the Canadian International Council to publish Canada's leading international affairs journal. Our board member Dr. MacDonald will be co-editor and our conferences and speakers will provide content for this important journal that has deeply influenced the study of international affairs in Canada and elsewhere," said John English, Director of the CCIH.

Jennifer Jeffs, President of the Canadian International Council (CIC) added, "The journal is Canada's leading journal of international affairs and plays a key role in our mission to be a major voice in the international policy arena. SAGE is well known for its core strengths as a high quality publisher within international policy, and we see clear synergies with our core values and global publishing goals. We look forward to developing an influential relationship together."

###

SAGE is a leading international publisher of journals, books and electronic media for academic, educational, and professional markets. Since 1965, SAGE has helped inform and educate a global community of scholars, practitioners, researchers, and students spanning a wide range of subject areas including business, humanities, social sciences, and science, technology and medicine. SAGE has principal offices in Los Angeles, London, New Delhi, Singapore and Washington DC. http://www.sagepublicaions.com

International Journal (IJ) has been recognized as Canada's pre-eminent scholarly publication on international relations since its inception in 1946. Readers benefit from wide-ranging research and analysis by scholars, practitioners, and policy-makers, Canadian and non-Canadian.

Canadian International Council (CIC) is a non-partisan, nationwide council established to strengthen Canada's role in international affairs. It aims to advance research and dialogue on international affairs issues by supporting a Canadian foreign policy network that crosses academic disciplines, policy areas, and economic sectors.

Bill Graham Centre for Contemporary International History (CCIH) is a joint undertaking of Trinity College and the Munk School of Global Affairs at the University of Toronto. It promotes the study of recent international events from a historical standpoint, and pursues programs of research, teaching, publication and other activities to that end.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/sp-stp042913.php

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Pearl Osbourne ?Went Insane? Trying First Cupcake

"Pearl had her first cupcake - just a little bit of a vanilla one. She went insane - it was unbelievable to see it. She was shaking with excitement," the proud grandmother tells PEOPLE.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/NgbNyhEPQtg/

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Monday, April 29, 2013

Monday Brief: WWDC sells out, BlackBerry Q10 review and the Samsung Galaxy S4 has arrived

Mobile Nations

 

 

 

 

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/Wy4HlXhiB3E/story01.htm

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Avalanche fire coach Joe Sacco

Colorado Avalanche head coach Joe Sacco, back, looks on as his players take a break during a time out against the Minnesota Wild in the second period of an NHL hockey game in Denver on Saturday, April 27, 2013. (AP Photo/David Zalubowski)

Colorado Avalanche head coach Joe Sacco, back, looks on as his players take a break during a time out against the Minnesota Wild in the second period of an NHL hockey game in Denver on Saturday, April 27, 2013. (AP Photo/David Zalubowski)

(AP) ? Colorado Avalanche coach Joe Sacco was fired on Sunday after the team missed the playoffs for the third straight season.

The Avs never got on track in the lockout-shortened season and finished last in the Western Conference.

Sacco was in his fourth season in charge of Colorado and wound up with a 130-134-30 mark. He had one year left on his contract.

"The organization believes a change of leadership behind the bench is needed going forward," general manager Greg Sherman said in a release. "Joe has worked for this franchise for eight seasons and he is a dedicated and hard-working coach. We appreciate all he has done and wish him the best in the future."

The Avs will soon begin their search for a replacement.

Sacco spent two seasons in charge of the organization's American Hockey League affiliate squad, the Lake Erie Monsters, before taking over the Avs in 2009 after the firing of Tony Granato.

A former NHL player, Sacco preached a fast-paced style and it served the youthful Avalanche well in his first season as the team earned a postseason spot. He was even a finalist for the NHL's coach of the year.

But Colorado couldn't duplicate that success.

Moments after a 3-1 loss to Minnesota on Saturday to close out the regular season, Sacco was asked about his future, saying, "We're certainly headed in the right direction."

His team was committed to his up-tempo philosophy. Matt Duchene recently said that Sacco's message was still getting across.

"We've all played the system he's put in place to the best of our ability. We've all worked at it," said Duchene, who finished tied with P.A. Parenteau for the team scoring lead with 43 points. "We're all still buying in and working."

Sacco will be back on the bench later this week when he leads the U.S. squad at the world championships. He will even take several Avalanche players with him, including Paul Stastny and Erik Johnson.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-28-HKN-Avalanche-Sacco-Fired/id-d2ac35b07d1e42088478dcb7a53557c9

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Iraq instability tested further with bombing wave

BAGHDAD (AP) ? A wave of car bomb blasts tore through Shiite areas south of Baghdad on Monday, killing at least 36 and deepening fears that Iraq is rapidly spiraling back out of control.

The attacks capped a week of turmoil that is posing the greatest test of Iraq's stability since U.S. troops left the country in late 2011. At least 218 people have been killed in attacks and battles between gunmen and security forces that began with clashes at a Sunni protest camp in northern Iraq last Tuesday.

The unrest follows four months of widespread protests among Iraq's Sunni minority, who feel they are discriminated against and are being marginalized by Prime Minister Nouri al-Maliki's Shiite-led government.

Iraqi officials fear that Sunni feelings of disenfranchisement could be exploited by extremist groups such as al-Qaida and militant organizations such as the Naqshabandi Army, which is linked to Saddam Hussein's former regime.

In a possible sign of mounting worries over the deteriorating security situation, Iraqi authorities announced they plan to close the country's only border crossing with Jordan, beginning on Tuesday. The Interior Ministry said the move is related Iraq's domestic affairs.

The route to the border runs through the cities of Ramadi and Fallujah, west of Baghdad, which have been hotbeds of Sunni anger at the government. Many Sunnis in western Iraq have economic, tribal and cultural ties with Jordanians, most of whom are also Sunni.

Sheik Fakhir al-Kubaisi, a protest organizer in Anbar province, blasted the latest closure plans as "another escalation by the Iraqi government to punish the revolting Iraqi people." He predicted the closure would drive up the prices of food and medicine, and might be tied to a coming security crackdown on protest sites in the area.

The Interior Ministry spokesman, Lt. Col. Saad Maan Ibrahim, insisted the border closure was solely a technical matter and is unrelated to ongoing tensions in the country. He did not elaborate, and said it should reopen within 48 hours.

Iraq temporarily shut the same border crossing in January, weeks after anti-government protests erupted along the desert highway heading to the checkpoint. That angered many Sunnis in western Iraq, who saw it as collective punishment for their rallies.

The International Crisis Group recently warned that the standoff between Sunni protesters and the central government has begun a dangerous slide toward confrontation.

"The emergence of an arc of instability and conflict linking Lebanon, Syria and Iraq, fueled by sectarianism and involving porous borders as well as cross-border alliances, represents a huge risk," the conflict-prevention group warned. "Failure to integrate Sunni Arabs into a genuinely representative political system in Baghdad risks turning Iraq's domestic crisis into a broader regional struggle."

Monday's deadliest attack struck the southern city of Amarah. Two parked cars loaded with explosives went off simultaneously in the early morning near a gathering of construction workers and a market, killing 18 people and wounding 42, the police said.

That attack was followed by another parked car bombing near a restaurant in the city of Diwaniyah, killing nine people and wounding 23. At least three cars were left charred and twisted from the blast outside a two-story building, and its facade was damaged. Shop owners and cleaners were seen brushing debris off the bloodstained pavement.

Amarah, some 320 kilometers (200 miles) southeast of Baghdad, and Diwaniyah, 130 kilometers (80 miles) south of the capital, are heavily Shiite and usually peaceful.

Hours later, yet another car bomb went off in the Shiite holy city of Karbala, killing three civilians and wounding 14, police said. Two early Islamic figures revered by Shiites are buried in the city, about 90 kilometers (55 miles) south of Baghdad.

And in the otherwise predominantly Sunni town of Mahmoudiya, about 20 miles (30 kilometers) south of Baghdad, a car bomb ripped through a Shiite neighborhood, killing six people and wounding 14, another police officer said.

Ibrahim Ali, a schoolteacher there, was teaching a class when a thunderous boom went off.

"The students were panicking and some of them started to cry," he said, recounting seeing burned bodies and cars on fire at the nearby blast site. "We have been expecting this violence against Shiites because of the rising sectarian tension in the country," he said.

Medical officials confirmed the casualty figures. Like the police, they spoke on condition of anonymity because they were not authorized to talk to the media.

No one immediately claimed responsibility for Monday's blasts. But coordinated bombings in civilian areas are a favorite tactic for al-Qaida in Iraq.

Parliament speaker Osama al-Nujaifi, a Sunni, condemned Monday's bombings and urged the government to step down "in order to save the country from the specter of civil war and sectarian strife." He called for the installation of an interim government, dissolution of parliament and early elections.

He issued a similar call in February for the prime minister to step down and for early elections, but there is little sign for now of that happening.

Sectarian violence has spiked since last Tuesday, when security forces tried to make arrests at a Sunni Muslim protest camp in the northern city of Hawija. The move set off a clash that killed 23 people, including three soldiers.

In Baghdad, al-Maliki met on Monday with the prime minister of Iraq's largely autonomous Kurdish region, Nechirvan Barzani.

A statement from the Iraqi leader's office said the two sides discussed their differences "in an atmosphere of frankness and seriousness and with a common desire to find solutions."

Ongoing disputes between Baghdad and the Kurds over sensitive issues such as ethnically disputed territories and how to manage the country's vast oil wealth further undermine Iraq's stability as al-Maliki tries to manage relations with the country's Sunni Arabs.

In other violence Monday, several mortar shells exploded in an uninhabited area near Baghdad International Airport around sunset, but no casualties were reported, police said.

An Iranian exile group whose members live in a refugee camp near the airport described the explosions as rocket strikes. It said they hit water canals at the southern part of the camp.

The group, the National Council of Resistance of Iran, has been pushing for camp residents, members of its Mujahedeen-e-Khalq militant wing, to be moved back to another camp north of Baghdad. Iraq's government wants them out of the country altogether.

___

Associated Press writers Sinan Salaheddin and Sameer N. Yacoub contributed to this report.

___

Follow Adam Schreck on Twitter at http://twitter.com/adamschreck

Source: http://news.yahoo.com/iraq-instability-tested-further-bombing-wave-172820332.html

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FBI director faces criticism of bureau again

By Susan Cornwell and Thomas Ferraro

WASHINGTON (Reuters) - As he nears the end of a dozen years as director of the FBI, Robert Mueller finds himself defending the agency over its handling of two high-profile cases. It is a familiar spot for the low-key ex-Marine.

At the request of President Barack Obama, Mueller stayed on for two years beyond the job's 10-year term to help stabilize law enforcement's fight against domestic and international threats to U.S. security. Recent events - the bombing at the Boston Marathon and ricin-laced letters sent to Obama and a U.S. senator - have left Mueller dealing with suggestions that agency missteps may have added to the damage.

Mueller, 68, who is scheduled to leave office in early September, has endured many congressional attacks against his agency's performance. While he is not universally praised on Capitol Hill, he has won enough bipartisan support to be considered a success.

Tellingly, it was a target of the 2001 anthrax letters - Democratic Senator Patrick Leahy of Vermont - who told Mueller at a 2008 hearing that he seriously doubted the findings of the FBI's long and complicated anthrax investigation. But three years later, Leahy as Senate Judiciary Committee chairman helped Mueller win a two-year extension of his term.

The FBI chief gets far milder treatment than some other prominent members of the 0bama administration, such as U.N. Ambassador Susan Rice. She came under heavy fire from Republicans for remarks she made after the September 11, 2012, attack on the U.S. Mission in Benghazi in which four Americans were killed, including Ambassador Chris Stevens.

In Washington, where making enemies is easy, Mueller wins high scores from members of Congress for his competence, even as he guided a vast expansion of FBI powers since the hijacked plane attacks of September 11, 2001.

"I believe he is well liked, even though I find fault with a lot of his policies, or how he does things," Senator Charles Grassley, the top Republican on the Judiciary Committee, said in an interview. "I think he's well intentioned ... it's kind of difficult for me to criticize him even when there is a screw-up," Grassley added.

This month, the FBI has faced fresh assaults over its failure to spot the potential danger from Tamerlan Tsarnaev, a suspect in the April 15 Boston Marathon bombings, after Russia asked the bureau to investigate him two years ago. Tamerlan Tsarnaev died in a police shootout and his brother, Dzhokhar Tsarnaev, has been charged in the bombings that killed three people and injured more than 200.

Two senior Republican lawmakers complained Tamerlan Tsarnaev was yet another in a series of cases in which a person investigated by the agency had later taken part in attacks.

Soon after the Boston bombings, the FBI accused an Elvis impersonator of sending letters containing ricin to Obama and other officials, only to quickly drop the charges for a lack of evidence.

Mueller and his leadership team have briefed members of Congress about the cases, but further inquiries are likely.

"I think he is ready to go home. He has had 12 years," said Dutch Ruppersberger, the top Democrat on the House of Representatives Intelligence Committee. He praised Mueller, who was first nominated to the job by a Republican president, George W. Bush.

"He has had some major issues to confront, including 9/11, then Russian and China threats, cyber threats," he said.

Some lawmakers say that despite the Boston blasts, the FBI thwarted other plots in recent years, including one to bomb New York's subway system. They also note that there was an arrest within days of the Boston bombing.

"I thought they (the FBI) did fabulous in getting to the bottom of the Boston bombing, but as great as that was, it was embarrassing to bring in a guy who had nothing to do with the ricin mailings," said Representative Louie Gohmert, a Texas Republican who serves on the Judiciary Committee, which has oversight of the FBI.

Mueller's office did not comment, although Mueller has praised the work of the FBI and other law enforcement agencies for the arrest of the Boston bombing suspect.

LOW PROFILE?

Some think Mueller's secret to success has been keeping a low profile in a town where many people are constantly angling to get attention. Mueller, while doing a lot of closed-door briefings for leaders, does not talk much to the media.

"I think he has been successful because he hasn't been a press hog," Grassley said.

Mueller, a former Justice Department official, was nominated for the top FBI job in 2001 and took office days before the September 11 attacks on New York and Washington.

When Obama asked Mueller to stay on, some Senate Republicans initially balked. One, Senator Rand Paul of Kentucky, came around after Mueller met with him to discuss the bureau's handling of a Kentucky case.

Mueller fielded heavy criticism from his earliest days in office.

After the 9/11 attacks, politicians from both parties questioned how the FBI had missed several warning signs of the hijackings, such as a memo from a Phoenix agent about Middle Eastern men taking flight lessons.

The anthrax case led to criticism because the bureau focused for so long on the wrong man, a mistake that ultimately cost the government millions of dollars in settling a lawsuit.

The FBI finally concluded that Army scientist Bruce Ivans was responsible for the anthrax attacks, but he killed himself before charges were brought.

In 2008, Leahy, then the Democratic chairman of the Judiciary Committee, told Mueller he did not believe the FBI finding that Ivans was solely responsible. Leahy said he thought others had to be involved.

Mueller reorganized the FBI to expand its analytical capability and improve its intelligence collection. He also beefed up its bioterrorism capabilities.

He has been praised for resisting some parts of the expansion of domestic surveillance under Bush.

Grassley said Mueller had not always been as responsive as possible to the senator's letters or "as protective of whistleblowers as he should be."

But he said there should not be another extension as director for Mueller, no matter how well liked he may be.

The purpose of the law limiting the director's term "is to make sure we don't get into this J. Edgar Hoover syndrome, that one guy is so indispensable," Grassley said, referring to the former FBI director of almost four decades. "We don't want to get caught in that syndrome again."

(Reporting By Susan Cornwell; Editing by Marilyn W. Thompson and Peter Cooney)

Source: http://news.yahoo.com/fbis-longtime-director-faces-criticism-bureau-again-122025633.html

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Sunday, April 28, 2013

Mapping of cancer cell fuel pumps paves the way for new drugs

Mapping of cancer cell fuel pumps paves the way for new drugs [ Back to EurekAlert! ] Public release date: 28-Apr-2013
[ | E-mail | Share Share ]

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer. In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia coli bacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters", says Pr Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of the transport protein facilitates the development of better drugs in a shorter time. Such GLUT inhibitors could potentially be used to treat cancer in the future."

The study may be of significance not just to cancer research but also in the field of diabetes. GLUT plays a key role in diabetes since insulin works by activating the uptake of glucose from the blood by means of GLUT transporters in the cell membrane.

GLUT and the studied XylE transporter belong to the very large group of metabolite transporters called the Major Facilitator Superfamily (MFS), which is important in many diseases and for the uptake of medicines in cells.

"Many aspects concerning molecular mechanisms for the function of GLUT transporters are probably common to many members of the MFS family, which are involved in a broad spectrum of diseases in addition to cancer and diabetes," says Pr Nordlund.

As well as membrane transporters, which have undergone in-depth analysis in the current study, many different membrane proteins pass through the surface membrane of the cells. Their significance to the cell function and the development of drugs has been noted before, not least through the Nobel Prizes that were awarded to researchers who used mechanistic and structural studies to map the function of two other major membrane protein families, G-protein-coupled receptors and ion channels.

###

The current study has been financed by grants from the Swedish Research Council, the Swedish Cancer Society, the European Molecular Biology Organization (EMBO) and The Danish Council for Independent Research.

Publication: 'Structural basis for substrate transport in the GLUT homology family of monosaccharide transporters', Esben M. Quistgaard, Christian Lw, Per Moberg, Lionel Trsaugues, and Pr Nordlund, Nature Structural & Molecular Biology, online 28 April 2013, doi: 10.1038/nsmb.2569. EMBARGOED until Sunday 28 April 2013 at 18:00 UK time / 19:00 CET / 13:00 US ET.

Journal website: http://www.nature.com/nsmb

Contact the Press Office: ki.se/pressroom

Karolinska Institutet a medical university: ki.se/english


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Mapping of cancer cell fuel pumps paves the way for new drugs [ Back to EurekAlert! ] Public release date: 28-Apr-2013
[ | E-mail | Share Share ]

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer. In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia coli bacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters", says Pr Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of the transport protein facilitates the development of better drugs in a shorter time. Such GLUT inhibitors could potentially be used to treat cancer in the future."

The study may be of significance not just to cancer research but also in the field of diabetes. GLUT plays a key role in diabetes since insulin works by activating the uptake of glucose from the blood by means of GLUT transporters in the cell membrane.

GLUT and the studied XylE transporter belong to the very large group of metabolite transporters called the Major Facilitator Superfamily (MFS), which is important in many diseases and for the uptake of medicines in cells.

"Many aspects concerning molecular mechanisms for the function of GLUT transporters are probably common to many members of the MFS family, which are involved in a broad spectrum of diseases in addition to cancer and diabetes," says Pr Nordlund.

As well as membrane transporters, which have undergone in-depth analysis in the current study, many different membrane proteins pass through the surface membrane of the cells. Their significance to the cell function and the development of drugs has been noted before, not least through the Nobel Prizes that were awarded to researchers who used mechanistic and structural studies to map the function of two other major membrane protein families, G-protein-coupled receptors and ion channels.

###

The current study has been financed by grants from the Swedish Research Council, the Swedish Cancer Society, the European Molecular Biology Organization (EMBO) and The Danish Council for Independent Research.

Publication: 'Structural basis for substrate transport in the GLUT homology family of monosaccharide transporters', Esben M. Quistgaard, Christian Lw, Per Moberg, Lionel Trsaugues, and Pr Nordlund, Nature Structural & Molecular Biology, online 28 April 2013, doi: 10.1038/nsmb.2569. EMBARGOED until Sunday 28 April 2013 at 18:00 UK time / 19:00 CET / 13:00 US ET.

Journal website: http://www.nature.com/nsmb

Contact the Press Office: ki.se/pressroom

Karolinska Institutet a medical university: ki.se/english


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/ki-moc042613.php

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Obama jokes about aging during 2nd term

President Barack Obama speaks at the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

President Barack Obama speaks at the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

Michael Douglas poses for a photo during the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

President Barack Obama talks with Michael Clemente, Executive Vice President of Fox News, the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

President Barack Obama looks to the podium during the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

First lady Michelle Obama, right, and late-night television host Conan O'Brien attend the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

(AP) ? President Barack Obama joked Saturday that the years are catching up to him and he's not "the strapping young Muslim socialist" he used to be.

Obama poked fun at himself as well as some of his political adversaries during the annual White House Correspondents' Association dinner attended by politicians, members of the media and Hollywood celebrities.

Entering to the rap track "All I Do Is Win" by DJ Khaled, Obama joked about how re-election would allow him to unleash a radical agenda. But then he showed a picture of himself golfing on a mock magazine cover of "Senior Leisure."

"I'm not the strapping young Muslim Socialist that I used to be," the president remarked, and then recounted his recent 2-for-22 basketball shooting performance at the White House Easter Egg hunt.

But Obama's most dramatic shift for the next four years appeared to be aesthetic. He presented a montage of shots featuring him with bangs similar to those sometimes sported by his wife.

"So we borrowed one of Michelle's tricks," Obama said. "I thought this looked pretty good, but no bounce."

Obama closed by noting the nation's recent tragedies in Massachusetts and Texas, praising Americans of all stripes from first responders to local journalists for serving the public good.

Saturday night's banquet not far from the White House attracted the usual assortment of stars from Hollywood and beyond. Actors Kevin Spacey, Julia Louis-Dreyfus and Claire Danes, who play government characters on series, were among the attendees, as was Korean entertainer Psy. Several Cabinet members, governors and members of Congress were present.

And despite coming at a somber time, nearly two weeks after the deadly Boston Marathon bombing and 10 days after a devastating fertilizer plant explosion in West, Texas, the president and political allies and rivals alike took the opportunity to enjoy some humor. Late-night talk-show host Conan O'Brien headlined the event.

Some of Obama's jokes came at his Republican rivals' expense. He asked that the GOP's minority outreach begin with him as a "trial run" and said he'd take his recent charm offensive with Republicans on the road, including events with conservatives such as Sen. Ted Cruz, Sen. Rand Paul and Rep. Michele Bachmann.

"In fact, I'm taking my charm offensive on the road -- a Texas barbeque with Ted Cruz, a Kentucky bluegrass concert with Rand Paul, and a book-burning with Michele Bachmann," Obama joked.

Casino magnate Sheldon Adelson would have had better success getting Obama out of office if he simply offered the president $100 million to drop out of last year's race, Obama quipped.

And on the 2016 election, the president noted in self-referential irony that potential Republican candidate Sen. Marco Rubio wasn't qualified because he hasn't even served a full term in the Senate. Obama served less than four years of his six-year Senate term before he was elected president in 2008.

"I mean, the guy has not even finished a single term in the Senate and he thinks he's ready to be President," Obama joked.

The gala also was an opportunity for six journalists, including Associated Press White House Correspondent Julie Pace, to be honored for their coverage of the presidency and national issues.

The New Yorker's Ryan Lizza won the Aldo Beckman Award, which recognizes excellence in the coverage of the presidency.

Pace won the Merriman Smith Award for a print journalist for coverage on deadline.

ABC's Terry Moran was the winner of the broadcast Merriman Smith Award for deadline reporting.

Reporters Jim Morris, Chris Hamby and Ronnie Greene of the Center for Public Integrity won the Edgar A. Poe Award for coverage of issues of national significance.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-28-Obama-Correspondents/id-09d4febe6e4d4128a38db58294475600

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Sponsor Me

this seems like its going to be a great rp, so i'm in, if you'll have me~~ ^u^

I know I want a vampire character at the very least, but i'm between an empathetic and a shapeshifter. Though i think i'm leaning more towards empathetic vampire.

And i dunno i think i might make a human too if thats cool. (if there are any like character types that are specifically needed that could help my decision and stuff)

I do just have one question, and this in no way is like a deal breaker for me, obviously, but it helps me out while im doing character development - is sexual orientation for characters free game or just standard? Sorry if this is a dumb question but if you skimmed through my characters pretty much all of them are pansexual, and the orientation almost always affects their entire character.

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Saturday, April 27, 2013

Pale Plague

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Pale Plague

It began 40 years ago. A plague which turns man and beast into monstrous beings. Somehow, many humans survived the plague, but it continues to spread. Now, only the Plague Doctors can help.

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Japan clears 787s for takeoff pending FAA-approved battery fix

DNP

Japan's transport minster, Akihiro Ohta, announced today that the country's airliners can resume flying grounded Boeing 787 Dreamliners once a newly approved battery system is installed. "We have reached a conclusion that there is no problem with the judgment by the FAA," Ohta told the Associated Press. Back in January two separate fires caused by the 787's lithium ion batteries led to the FAA temporarily grounding all Dreamliners. Japan's decision comes shortly after Boeing's CEO, Jim McNerney, stated during the company's recent fiscal conference call that he expected all 50 aircraft to be fixed by the middle of May. Japanese airline officials are forecasting a slightly longer timeline, with the country's 787s returning to the skies around June and test flights scheduled to begin on April 28th.

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Friday, April 26, 2013

Conrad Murray: ?An injustice has occurred?



>> conrad murray who was convicted of involuntary manslaughter in the death of michael jackson speaks out live from his los angeles jail cell , but first nbc's take taibbi has new details on dr. murray 's attempt to have his conviction overturned. mike, good morning to you.

>> reporter: good morning, savannah. at this point dr. murray 's appeal isn't intended to shorten his prison sentence . he's due to be releelsreleased soon. probably by the fall. it's to that he did nothing wrong. before he was convicted of involuntary manslaughter and sentenced to the max, four years, he told savannah that michael jackson 's death had nothing to do with the care he provided.

>> do you feel guilty that he died?

>> i don't feel guilty because i did not do anything wrong.

>> reporter: in his appeal, murray says his trial was fundamentally unfair, the trial judge was biased and the jury should have been sequestered because of the media frenzy around the case. his goal not to get out of jail early but to get his life back, says attorney valerie walsh.

>> he wouldn't be a convicted felon for one thing. he wouldn't lose the rights as a felon, it may lose his ability to practice medicine in the future.

>> reporter: murray could be a turning point witness in the jackson family 's mega millions suit against the promoters of the king of pop 's doomed final concert tour . if the doctor's negligence led to the final fatal dose of propofol who was the role of aig live who murray believed would be paying his monthly $150,000 fee? law professor lori levinson.

>> the jackson family will argue aig is responsible for everything conrad murray did. they reminded him they're in charge.

>> reporter: murray has not been subpoenaed to testify in the suit against aig though he's on the witness list for both sides. aeg says the company didn't hire murray and had nothing to do with jackson's medical care . murray says he'll likely take the fifth if he's called to testify.

>> mike taibbi thank you so much. dr. conrad murray is with us exclusively on the phone from the men's central jail in los angeles . his attorney valerie wasser is here, handling his appeal.

>> good morning, savannah.

>> dr. murray , this is not about shortening your sentence. you're expected to be out in a few months. as i understand it, this appeal is for you, a chance to clear your name. do you think it will be sufficient to do that and do you expect you should be able to practice medicine again?

>> well, i hope that i think my attorney has done an excellent job in her brief and i hope that the court would see that an injustice has occurred at this occasion and if that be the case, i will have my license back and i'll be able to continue practicing medicine to give services to all those who seek it and especially to the underserved.

>> in your appeal which i have seen, you blame michael jackson . you blame the jury. you blame the judge, and you blame your lawyers and i wonder if, having reflected on these facts now, you take any personal responsibility for what happened to michael jackson .

>> not any responsibility as it relates to his death. i am sorry that i have lost michael as a friend and as a patient. being a doctor almost, such a huge impact on our lives, to have to tell a family member someone has passed away , you could not save them. it's a tremendous loss, so much pain and i have lost a very dear friend and a dear person to me, and it's going to remain with me for the rest of my life but i'm not going to accept responsibility for anything i did not do.

>> but doctor, let me push back on that just a little bit. he died from this powerful anesthetic called propofol as you well know. you prescribed it and you administered it. i know your theory is he injected it, however, are you not responsible for bringing the drug into the room and leaving him unattended?

>> that, i am not. i met michael jackson with his own stash of medication. i tried to get rid of the propofol from michael jackson . you may not have liked the approach i took but nonetheless, the circumstances were to actually get him away from that agent.

>> speaking of the night he died, doctor, in just those actions, you left the room, you left him unattended, and pro to follow on the package labeling says it requires constant monitoring.

>> i left the room but i left no propofol in his way he should have used, i did not leave it to michael to have taken his own action and cause his own demise. i did not do that.

>> let me let valerie on this.

>> jackson was not on a pro to follow drip. he was on a saline drip. he's given him 25 milligrams of propofol .

>> that's doctor murray 's contenti contention. there was a larger amount of propofol found in his autopsy.

>> correct.

>> you don't dispute the fact that propofol was prescribed and michael jackson gained access to it when dr. murray left the room.

>> gained access whether it came from dr. murray or his own source has not been established.

>> dr. murray , let me ask you what life in jail has been like for you?

>> it has been one of my most horrendous experience. i have only survived because of the loving hope and the support that i get from various individuals and especially would like to say my girlfriend, any koes nicole alvarez, never missed a visitation and never not called me on a daily basis and my children and just a bunch of other people who have written to me from all over the world who encourage me.

>> do you regret not taking the stand in your own defense?

>> i don't know. i do not think that the prosecution had solved or they had proved their case, and i did not see if i took the stand if i would have added anything more. i believe the problem is my attorneys. i believe there was a lot of ineffectiveness. actually there was an obstruction of justice when the prosecutor himself destroyed the evidence in the open courtroom. that was obstruction of justice, and that was unbelievable. that is almost i think impossible to live with.

>> dr. conrad murray , we appreciate you getting up early, calling us from your jail cell . we appreciate it, and valerie wass, thank you to you.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b346e1c/l/0Lvideo0Btoday0Bmsnbc0Bmsn0N0Cid0C51673562/story01.htm

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Global Approval for Domestic Abuse Down

Around the world, domestic violence has become much less socially acceptable, new research suggests.

Views on domestic violence changed dramatically since 2003 in 26 middle- and low-income countries across the world, according to a study detailed in the April issue of the journal American Sociological Review. Half of the countries surveyed were in sub-Saharan Africa.

In Nigeria, for instance, 65 percent of men and 52 percent of women rejected domestic violence in 2008, compared with just 48 percent and 33 percent five years earlier.

Still, the data, which were collected by the United States Agency for International Development ?(USAID) from hundreds of thousands of people, shows that violence against women is still widely accepted. And in two countries ? Indonesia and Madagascar ? tolerance for domestic violence actually increased.

The survey asked people how justified men were in beating wives for things such as going out without letting her husband know, neglecting the children, arguing with her husband, refusing sex or burning food.

Unsurprisingly, those who live in urban areas and had more education were likelier to reject wife beating. Access to media such as television or newspapers also increased disapproval for domestic violence.

Interestingly, in 11 of 15 countries, men were more likely to reject domestic violence than women.

The attitude adjustments were found across societies.

"Often it's the case that social change starts with younger people," said study co-author Rachael Pierotti, a graduate student at the University of Michigan, in a statement. "But in this case, people of all ages became more rejecting of domestic violence."

Follow Tia Ghose on Twitter @tiaghose.?Follow?LiveScience @livescience, Facebook?& Google+. Original article on?LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/global-approval-domestic-abuse-down-124136042.html

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